Volume 2.44 | Nov 7

Pulmonary Cell News 2.44 November 7, 2013
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Sox9 Plays Multiple Roles in the Lung Epithelium during Branching Morphogenesis
Scientists describe a role for the transcription factor Sox9 during lung branching morphogenesis. Sox9 is expressed at the distal tips of the branching epithelium in a highly dynamic manner as branching occurs and is down-regulated starting at embryonic day 16.5, concurrent with the onset of terminal differentiation of type 1 and type 2 alveolar cells. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS ( Ranked by impact factor of the journal)
Neonatal Hyperoxia Stimulates the Expansion of Alveolar Epithelial Type II Cells
Since hyperoxia inhibits cell proliferation, researchers hypothesized it depletes the adult lung of type II cells by inhibiting their proliferation at birth. Newborn mice were exposed to room air or hyperoxia and the oxygen-exposed mice were recovered in room air. [Am J Respir Cell Mol Biol] Abstract

NADPH Oxidase Mediates Synergistic Effects of IL-17 and TNF-α on CXCL1 Expression by Epithelial Cells after Lung Ischemia-Reperfusion
Scientists tested the hypothesis that IL-17 and TNF-α synergistically mediate CXCL1 (a potent neutrophil chemokine) production by alveolar type II epithelial cells via an NADPH oxidase-dependent mechanism during lung ischemia-reperfusion. [Am J Physiol Lung Cell Mol Physiol] Abstract

Altered MicroRNA Expression Profile during Epithelial Wound Repair in Bronchial Epithelial Cells
To investigate the possible involvement of microRNA (miRNA) in epithelial repair, investigators analyzed miRNA expression profiles during epithelial repair in a cell culture model using TaqMan-based quantitative real-time PCR in a TaqMan Low Density Array format. [BMC Pulm Med] Abstract | Full Article

Penta- and Octa-Bromodiphenyl Ethers Promote Proinflammatory Protein Expression in Human Bronchial Epithelial Cells In Vitro
Investigators examined commercial penta-diphenyl ethers (BDEs), octa-BDE, and deca-BDE. Human bronchial epithelial cells were exposed to each polybrominated diphenyl ethers for 24 hours. Subsequently, the expression of intercellular adhesion molecule-1 and proinflammatory cytokines were investigated. [Toxicol In Vitro] Abstract

Inhibition of Toll-Like Receptor 2-Mediated Response in Human Alveolar Epithelial Cells by Mycolic Acids and Mycobacterium tuberculosis mce1 Operon Mutant
Researchers compared the chemokine expression patterns of human epithelial cell line A549 and RAW 264.7 macrophage cells infected with wild type M. tuberculosis H37Rv against patterns induced by a mutant that accumulates free mycolic acids in its cell wall. [Pathog Dis] Abstract

LUNG CANCER

A Gene Signature of Bone Metastatic Colonization Sensitizes for Tumor-Induced Osteolysis and Predicts Survival in Lung Cancer
Bone metastasis of lung adenocarcinoma is a frequent complication of advanced disease. Researchers aimed to identify key mediators conferring robust prometastatic activity with clinical significance. [Oncogene] Abstract

NEDD9 Promotes Lung Cancer Metastasis through Epithelial-Mesenchymal Transition
Researchers demonstrated that NEDD9 knockdown significantly inhibits migration, invasion and metastasis of lung cancer cells in vitro and in vivo. [Int J Cancer] Abstract

Ca2+/Calmodulin-Dependent Protein Kinase IIγ, a Critical Mediator of the NF-κB Network, Is a Novel Therapeutic Target in Non-Small Cell Lung Cancer
Scientists demonstrated that Ca2+/calmodulin-dependent protein kinase IIγ is a critical molecular switch of continuous activation of nuclear factor-kappa B (NF-κB) in non-small cell lung cancer. [Cancer Lett] Abstract

Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells
The glaucophyte Cyanophora paradoxa (Cp) was chemically investigated to identify pigments efficiently inhibiting malignant melanoma, mammary carcinoma and lung adenocarcinoma cells growth. Cp water and ethanol extracts significantly inhibited the growth of the three cancer cell lines in vitro, at 100 µg·mL−1. [Mar Drug] Abstract | Full Article

Potential Diagnostic Value of miR-155 in Serum from Lung Adenocarcinoma Patients
Using in vitro studies, the authors found that microRNA-155 (miR-155) could be a candidate plasmatic biomarker for diagnosing lung cancer. They assessed the differences in levels of miR-21, miR-155, carcinoembryonic antigen and carbohydrate antigen 125 expression in serum samples between lung cancer patients and healthy controls. [Oncol Rep] Abstract

Model the Human Respiratory Epithelium with PneumaCult™-ALI. Click to View Data.
 
REVIEWS
EGFR and KRAS Mutations, and ALK Fusions: Current Developments and Personalized Therapies for Patients with Advanced Non-Small-Cell Lung Cancer
This review focuses on the current and future biomarkers in the advanced non-small-cell lung cancer field and also addresses potential related targeted therapies for these patients. [Future Med] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
ImmunoGen, Inc. Announces Discontinuation of IMGN901 Study in Small-Cell Lung Cancer (SCLC)
ImmunoGen, Inc. announced the decision to stop the IMGN901 Phase II SCLC study, following the recommendation of the trial’s independent Data Monitoring Committee. ImmunoGen is in the process of updating study investigators and regulatory authorities. [ImmunoGen, Inc.] Press Release

Biothera’s Phase IIb Study in Non-Small Cell Lung Cancer Meets Primary Endpoint
Biothera announced top-line results from its Phase IIb clinical trial in non-small cell lung cancer that evaluated its immunotherapeutic drug candidate, Imprime PGG®, with cetuximab (Erbitux®), carboplatin and paclitaxel compared with the monoclonal antibody and chemotherapy combination alone. [Biothera, the immune health company] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW European Lung Cancer Conference (ELCC) 2014
March 26-29, 2014
Geneva, Switzerland

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Respiratory Research (Karolinska Institutet)

PhD Studentship – Epithelial Surfaces in the Lung (University of East Anglia)

Postdoctoral Scientist – Prognostic Biomarkers in Lung Cancer and Mesothelioma (Medical Research Council)

Postdoctoral Research Associate – Molecular Mechanisms of Endothelial Permeability, Vascular Inflammation, and Pulmonary Injury (University of Illinois)

Postdoctoral Research Fellow – Emphysema (University College Dublin)

Postdoctoral Research Associate – Airway Innate Defense and Biology (University of North Carolina – Chapel Hill)

Senior Postdoctoral Fellow – Mechanisms of Lung Injuries (University of Texas Health Science Center at Tyler)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)


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