Volume 2.31 | Aug 8

Pulmonary Cell News 2.31 August 8, 2013
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Tracking the Engraftment and Regenerative Capabilities of Transplanted Lung Stem Cells Using Fluorescent Nanodiamonds
Scientists showed that fluorescent nanodiamonds, in combination with fluorescence-activated cell sorting, fluorescence lifetime imaging microscopy and immunostaining, can identify transplanted CD45CD54+CD157+ lung stem/progenitor cells in vivo, and track their engraftment and regenerative capabilities with single-cell resolution. [Nat Biotechnol] Abstract
Learn More - Reduce Costs Associated With Collecting And Culturing Cells By Using Frozen Primary Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Nontoxic Impact of PEG-Coated Gold Nanospheres on Functional Pulmonary Surfactant-Secreting Alveolar Type II Cells
The present study investigates, for the first time, the impact of polyethyleneglycol (PEG) coated gold nanoparticles on freshly purified primary cultures of rat alveolar type II cells. [Nanotoxicology] Abstract

Localized Fgf10 Expression Is Not Required for Lung Branching Morphogenesis but Prevents Differentiation of Epithelial Progenitors
Researchers showed that Fgf10 prevents the differentiation of distal epithelial progenitors into Sox2-expressing airway epithelial cells in part by activating epithelial ß-catenin signaling, which negatively regulates Sox2 expression. [Development] Abstract

House Dust Mite-Induced Calcium Signaling Instigates Epithelial Barrier Dysfunction and CCL20 Production
Scientists investigated the effect of house dust mite on accumulation of intracellular Ca2+ concentration levels, barrier function, and CCL20 release in human bronchial epithelial 16HBE cells and primary bronchial epithelial cells from healthy subjects and asthma patients. [Allergy] Abstract

Cytochrome P450 2A13 Is an Efficient Enzyme in Metabolic Activation of Aflatoxin G1 in Human Bronchial Epithelial Cells
Human bronchial epithelial cells that stably express cytochrome P450 2A13 were used to conduct the effects of AFG1 on cytotoxicity, apoptosis, DNA damages, and their response protein expression. [Arch Toxicol] Abstract

Activation of Autophagy Rescues Amiodarone-Induced Apoptosis of Lung Epithelial Cells and Pulmonary Toxicity in Rats
Amiodarone treatment-induced autophagy in H460 human lung epithelial cells and BEAS-2B normal human bronchial epithelial cells was demonstrated by increased LC3-II conversion, Atg7 upregulation, and autophagosome formation. [Toxicol Sci] Abstract

LUNG CANCER

Notch-1 Contributes to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer In Vitro and In Vivo
The exact mechanism of Notch during acquisition of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) in human lung cancer remains unclear. Researchers showed that the expression of Notch-1 was highly upregulated in EGFR-TKI acquired resistant lung cancer cells. [Eur J Cancer] Abstract

Regulation of SIRT2 Levels for Human Non-Small Cell Lung Cancer Therapy
Investigators analyzed the expression pattern of sirtuin (SIRT)2 in non-small lung cancer (NSCLC) tissues from clinical patients and in cell lines, and found that SIRT2 was significantly down-regulated at both the mRNA and protein levels in tumor than non-tumor tissues or cells, which were corroborated by the NSCLC tissue microarray results. [Lung Cancer] Abstract

Axin Gene Methylation Status Correlates with Radiosensitivity of Lung Cancer Cells
After X-ray irradiation, xenograft growth was significantly decreased in H157 cells in comparison with LTE cells. Significantly decreased cell invasiveness and increased apoptosis were also observed in H157 cells treated with X-ray irradiation. [BMC Cancer] Full Article

Silibinin Meglumine, a Water-Soluble Form of Milk Thistle Silymarin, Is an Orally Active Anti-Cancer Agent that Impedes the Epithelial-to-Mesenchymal Transition (EMT) in EGFR-Mutant Non-Small-Cell Lung Carcinoma Cells
Because the EMT is required by a multiplicity of mechanisms of resistance to EGFR tyrosine kinase inhibitors, scientists evaluated the ability of silibinin meglumine to impede the EMT in vitro and in vivo. [Food Chem Toxicol] Abstract

Epithelial Membrane Protein 3 Is Frequently Shown Promoter Methylation and Functions as a Tumor Suppressor Gene in Non-Small Cell Lung Cancer
The expression and clinical significance of epithelial membrane protein 3 (EMP3) protein in lung cancer have not yet been elucidated. In vitro, following release from serum starvation of A549 NSCLC cells, the expression of EMP3 was deregulated. [Exp Mol Pathol] Abstract

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REVIEWS
Moving Forward: Cystic Fibrosis Gene Therapy
The authors review key studies with a particular emphasis on clinical findings. They have learnt that the lung is a more difficult target than originally anticipated and will describe the strength and weaknesses of the most commonly used airway gene transfer agents. [Hum Mol Genet] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.
 
INDUSTRY NEWS
LUNGevity Announces 2013 Lung Cancer Research Grants
LUNGevity Foundation announced that it has awarded $900,000 in new lung cancer research funds to six exceptional researchers through its Career Development and Targeted Therapeutics Awards programs. [LUNGevity Foundation] Press Release

AmpliPhi Presents Data on Bacteriophages in the Treatment of Lung Infections in Cystic Fibrosis
AmpliPhi BioSciences Corp. presented data relating to the use of bacteriophages in the treatment of Pseudomonas aeruginosa at the 20th Biennial Evergreen International Phage Meeting. [Business Wire]
Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW American Association of Respiratory Care (AARC) Congress 2013
November 16-19, 2013
Anaheim, United States

Visit our events page to see a complete list of events in the pulmonary cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Cancer Genomics (Fred Hutchinson Cancer Research Center)

PhD Position – Interaction of Nanoparticles with the Pulmonary Barrier (Helmholtz Institute for Pharmaceutical Research Saarland)

Postdoctoral Research Associate – Molecular Mechanisms of Endothelial Permeability, Vascular Inflammation, and Pulmonary Injury (University of Illinois at Chicago)

Postdoctoral Research Scientist – Asthma (Columbia University)

Postdoctoral Fellow – ERK3 Kinase Signaling in Cancer Progression and Metastasis (Wright State University)

Postdoctoral Researcher – Molecular Determinants of Resistance to Chemotherapy and Radiation (The Ohio State University – Comprehensive Cancer Center)

Postdoctoral Fellow – Translational Oncology (The University of Texas MD Anderson Cancer Center)

Director of Cell Processing Facility (S L Collins Associates, Inc.)


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