Volume 2.23 | Jun 13

Pulmonary Cell News 2.23 June 13, 2013
Pulmonary Cell News
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TOP STORY
Role of CXCL13 in Cigarette Smoke-Induced Lymphoid Follicle Formation and COPD
By neutralizing CXCL13 in a mouse model of chronic cigarette smoke (CS)-exposure, the authors aimed at interrogating the link between lymphoid follicles and development of pulmonary inflammation, emphysema and airway wall remodeling. Both mRNA and protein levels of CXCL13 were increased in lungs of CS-exposed mice and patients with COPD. [Am J Resp Crit Care] Abstract

PneumaCult™-ALI Medium for Bronchial Epithelial Cells: Watch the Video
PUBLICATIONS (Ranked by impact factor of the journal)

Sorafenib Ameliorates Bleomycin-Induced Pulmonary Fibrosis: Potential Roles in the Inhibition of Epithelial-Mesenchymal Transition and Fibroblast Activation
Scientists evaluated the antifibrotic effects of sorafenib on bleomycin-induced pulmonary fibrosis in mice. They further demonstrated that sorafenib not only profoundly inhibited transforming growth factor-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells, but also simultaneously reduced the proliferation and collagen synthesis in fibroblasts. [Cell Death Dis] Full Article

Caveolin-1 Controls Airway Epithelial Barrier Function: Implications for Asthma
Scientists studied expression of caveolin-1 and adhesion molecules E-cadherin and β-catenin in airway sections and cultured bronchial epithelial cells from asthma patients and healthy controls. Membrane expression of caveolin-1 was significantly lower in airway epithelium from asthma patients than non-asthmatics, which was maintained in vitro upon air-liquid interface and submerged culture. [Am J Resp Cell Mol] Abstract

CFTR Is Expressed in Mucin Granules from Calu-3 and Primary Human Airway Epithelial Cells
Researchers showed that CFTR and MUC5AC are both present in single mucin-containing granules isolated from a human airway epithelial cell line and from highly differentiated airway primary cell cultures. [Am J Resp Cell Mol] Abstract

Influenza A Infection of Primary Human Airway Epithelial Cells Up-Regulates Proteins Related to Purine Metabolism and Ubiquitin-Related Signaling
Investigators analyzed quantitative host protein alterations in nuclei-enriched fractions from multiple primary human bronchial airway epithelial cells infected by an H1N1 influenza A virus. [J Proteome Res] Abstract

Platelet Derived Growth Factor-A and Sonic Hedgehog Signaling Direct Lung Fibroblast Precursors during Alveolar Septal Formation
Researchers examined lung fibroblasts (LF) to learn whether platelet-derived growth factor-receptor alpha-expression distinguished a population of precursor cells, with enhanced proliferative and migratory capabilities. They identified a sub-population of LF which expresses sonic hedgehog and stem cell antigen-1. [Am J Physio-Lung C] Abstract

LUNG CANCER

ARF Inhibits the Growth and Malignant Progression of Non-Small-Cell Lung Carcinoma
KRAS and other oncogenes induce the expression of ARF, thus stabilizing p53 activity and arresting cell proliferation. To address the role of ARF in Kras-driven non-small-cell lung carcinoma, scientists compared the susceptibility of NIH/Ola strain wild-type and Arf-knockout mice to urethane-induced lung carcinogenesis. [Oncogene] Abstract

Chromogenic In Situ Hybridization Is a Reliable Assay for Detection of ALK Rearrangements in Adenocarcinomas of the Lung
Researchers validated a newly developed anaplastic lymphoma kinase (ALK) chromogenic in situ hybridization (CISH) assay by comparing fluorescent in situ hybridization and CISH signal patterns in lung cancer samples with and without ALK rearrangements. [Modern Pathol] Abstract

Ratiometric and Absolute Water-Soluble Fluorescent Tripodal Zinc Sensor and Its Application in Killing Human Lung Cancer Cells
A new “naked-eye” and ratiometric fluorescent zinc sensor of carboxamidoquinoline with 2-chloro-N-(quinol-8-yl)-acetamide as a receptor was designed and synthesized. The human lung cancer cell line (A549) activity was also demonstrated. [Analyst] Abstract

Polycyclic Aromatic Hydrocarbon-Induced Signaling Events Relevant to Inflammation and Tumorigenesis in Lung Cells Are Dependent on Molecular Structure
The authors used an isomeric pair of low molecular weight polycyclic aromatic hydrocarbons, namely 1-Methylanthracene (1-MeA) and 2-Methylanthracene (2-MeA), in which only 1-MeA possessed a bay-like region, and hypothesized that 1-MeA, but not 2-MeA, would affect non-genotoxic endpoints relevant to tumor promotion in murine C10 lung cells, a non-tumorigenic type II alveolar pneumocyte and progenitor cell type of lung adenocarcinoma. [PLoS One] Full Article

In Vitro and In Vivo Properties of CD133 Expressing Cells from Human Lung Cancer Cell Lines
From various cancer tissues or cancer cell lines, CD133 expressing cells were found to define a unique cancer stem cells/tumor-initiating cells phenotype. To study whether that also could be the case in lung cancer, researchers examined different lung cancer cell lines for CD133 expression. [Exp Hematol Oncol]
Abstract | Full Article

View On-Demand Webinar: Optimized Differentiation of Bronchial Epithelial Cells

REVIEWS

Long-Acting Anticholinergics in the Treatment of Asthma
There is a growing interest in the use of anticholinergic medications in the treatment of moderate to severe asthma. The purpose of this review is to summarize the scientific evidence for the use of anticholinergic therapy in the management of asthma. [Curr Opin Allergy Clin Immunol] Abstract

Epigenetic Therapy in Lung Cancer
The authors review the therapeutic implications of epigenetic changes in lung cancer, and recent advances in therapeutic strategies targeting DNA methylation and histone acetylation. [Front Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

INDUSTRY NEWS

Pearl Therapeutics to Be Acquired by Astrazeneca for up to $1.15 Billion
Pearl Therapeutics Inc. announced that it has entered into a definitive merger agreement under which the Company will be acquired by AstraZeneca. The acquisition will bring together Pearl’s pipeline of inhaled bronchodilator products for the treatment of patients with COPD and AstraZeneca’s core capabilities in respiratory disease. [Pearl Therapeutics Inc.] Press Release

LCA Announces $10.5 Million in Research Funding One Step Closer
Lung Cancer Alliance (LCA) announced that an additional $10.5 million for lung cancer research has been included in the House Appropriations FY2014 Department of Defense funding bill. [Lung Cancer Alliance]
Press Release

Novavax Produces MERS-CoV Vaccine Candidate
Novavax, Inc. announced that it had successfully produced a vaccine candidate designed to provide protection against the recently emerging Middle East Respiratory Syndrome Coronavirus (MERS-CoV). [Novavax, Inc.] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW Cold Spring Harbor Asia: Cell Signaling in Metabolism, Inflammation and Cancer
September 2-6, 2013
Suzhou, China

Visit our
events page to see a complete list of events in the pulmonary cell community.

JOB OPPORTUNITIES

NEW Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Associate – Mechanisms of Pathogenesis in Idiopathic Pulmonary Fibrosis (University of Minnesota)


Postdoctoral Position – Idiopathic Pulmonary Fibrosis (MedImmune UK Ltd)


Postdoctoral Position – Lung Development and Repair (Boston University Pulmonary Center)


PhD Studentships – Pulmonary Biology and Medicine (University of Giessen and Marburg Lung Center)


Postdoctoral Fellow – Stem Cell and Cancer Biology (Johns Hopkins University School of Medicine)

Postdoctoral Position – Respiratory Research (INSERM)


Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Post-doctoral Position – Mucosal Immunology (University of Southern California)

PhD Opportunity – Biofunctionalization of Liposomes for Tumor-Targeted Drug Delivery (University of East Anglia)

Postdoctoral Position – Pulmonary Research (Cedars-Sinai Medical Center)


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