Volume 2.05 | Feb 7

Pulmonary Cell News 2.05 February 07, 2013
Pulmonary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells In Vitro
Investigators report that pulmonary endothelial cells from caveolin-1 (Cav1) knockout mice displayed high levels of spontaneous Acta2, Col1A, Snai1, and Snai2 expression, which increased after transforming growth factor β (TGF-β) treatment. Spontaneous and TGF-β1-stimulated endothelial-to-mesenchymal transition were abrogated by the restoration of functional CAV1 domains using a cell-permeable peptide. [Am J Pathol] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary Disease
Scientists report that using a glucocorticoid response element (GRE) luciferase reporter transfected into human airway epithelial cells, roflumilast enhanced fluticasone propionate-induced GRE-dependent transcription. [Mol Pharmacol] Abstract

Macrolides Inhibit Fusobacterium nucleatum-Induced MUC5AC Induction in Human Airway Epithelial Cells
Researchers examined whether Fusobacterium nucleatum (Fn) induces mucin secretion in airway epithelial cells. They also examined the effects of macrolides on the Fn-induced mucus production compared with other antibiotics that exert anti-anaerobic activities. [Antimicrob Agents Ch] Abstract

Systematic Analysis of Multi-Walled Carbon Nanotube-Induced Cellular Signaling and Gene Expression in Human Small Airway Epithelial Cells
Researchers examined the cellular and gene expression changes in small airway epithelial cells (SAEC) after in vitro exposure to multi-walled carbon nanotubes (MWCNT) in an effort to elucidate potential toxicity mechanisms and signaling pathways. A direct interaction between SAEC and MWCNT was confirmed by both internalization of MWCNT as well as an interaction at the cell periphery. [Toxicol Sci] Abstract

Human Alveolar Epithelial Cells Attenuate Pulmonary Microvascular Endothelial Cell Permeability under Septic Conditions
Scientists report that human alveolar epithelial cells appear to protect human pulmonary microvascular endothelial cell barrier function under septic conditions in vitro, through release of a soluble mediator(s), which are at least partly lipid in nature. [PLoS One] Full Article

MARCKS and HSP70 Interactions Regulate Mucin Secretion by Human Airway Epithelial Cells In Vitro
The authors provide evidence of a role for heat shock protein 70 (HSP70) in mediating mucin secretion via interactions with myristoylated alanine-rich C kinase substrate (MARCKS), and that these interactions are critical for the cytoplasmic translocation of MARCKS upon its phosphorylation. [Am J Physiol-Lung C] Abstract

Biophysical Model of Ion Transport across Human Respiratory Epithelia Allows Quantification of Ion Permeabilities
Scientists used a biophysical model for water and ion transport to quantify ion permeabilities of all pathways (apical, basolateral, paracellular) in human nasal epithelia cultures using experimental data reported in the literature. [Biophys J] Abstract

LUNG CANCER


Prognostic Significance of the Combined Score of Endothelial Expression of Nucleolin and CD31 in Surgically Resected Non-Small Cell Lung Cancer
Investigators explored the expression and prognostic implication of nucleolin in surgically resected non-small cell lung cancer (NSCLC) patients. They demonstrated that nucleolin is associated with the clinical outcomes in postoperative NSCLC patients. [PLoS One] Full Article

Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer
Researchers established three orthotopic murine models of human small-cell lung cancer (SCLC) closely resembling the course of human SCLC seen in the clinic including metastasis to lymph nodes and distant organs. [J Thorac Oncol] Abstract

Lithium Enhances TRAIL-Induced Apoptosis in Human Lung Carcinoma A549 Cells
Scientists investigated whether lithium chloride (LiCl), a drug for mental illness, could sensitize non-small cell lung cancer A549 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. They observed that LiCl significantly enhanced A549 cells apoptosis through up-regulation of death receptors DR4 and DR5 and activation of caspase cascades. [Biometals] Abstract

Silencing SATB1 with siRNA Inhibits the Proliferation and Invasion of Small Cell Lung Cancer Cells
Investigators report that SATB1 protein was overexpressed in small cell lung cancer tissues and metastasis lymphoid nodes compared with adjacent normal lung tissues. [Cancer Cell Int] Abstract | Full Article

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REVIEWS
Novel Pharmacological Strategies to Treat Cystic Fibrosis
The authors review recent advances, strategies for the development of drugs from corrector compounds for the treatment of cystic fibrosis, and identification of their targets and mechanism(s) of action. [Trends Pharmacol Sci] Abstract | Full Article
INDUSTRY NEWS

American Lung Association Praises HUD Decision to Protect Families from Radon
The American Lung Association applauded the announcement from the U.S. Department of Housing and Urban Development (HUD) to protect families from the second leading cause of lung cancer (radon) that may be present in multifamily housing that HUD finances or refinances. [American Lung Association]
Press Release

Republic of Ireland Approves Funding for KALYDECO™ (ivacaftor), the First Medicine to Treat the Underlying Cause of Cystic Fibrosis, for People with a Specific Genetic Mutation (G551D)
Vertex Pharmaceuticals Inc., announced that the Health Service Executive in the Republic of Ireland will fund KALYDECO™ (ivacaftor), the first medicine to treat the underlying cause of cystic fibrosis, for people ages 6 and older who have at least one copy of the G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. [Vertex Pharmaceuticals Inc.] Press Release

Kala Pharmaceuticals Receives Cystic Fibrosis Foundation Grant
Kala Pharmaceuticals, Inc., a developer of innovative products that rapidly and effectively penetrate the mucosal barrier to treat a wide range of debilitating diseases, announced that it has been awarded a grant from the Cystic Fibrosis Foundation to demonstrate that Kala’s Mucosal-Penetrating Products also penetrate bacterial biofilms. [Kala Pharmaceuticals Inc.] Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

Tuberculosis: Understanding the Enemy
March 13-18, 2013
Whistler, Canada


Visit our events page to see a complete list of events in the pulmonary cell community.

JOB OPPORTUNITIES

Postdoctoral Fellows – Gene, RNA and Epigenetic Regulation, Protein Science, Signal Transduction, Cell and Stem Cell, Cancer and Other Diseases (Shanghai Institute of Biochemistry and Cell Biology)

Postdoctoral Position – Host-Pathogen Interaction at Mucosal Surfaces (Sanford Burnham Medical Research Institute)

Postdoctoral Fellowship – Translational Studies of Interstitial Lung Disease (University of California San Francisco)

Postdoctoral/ Research Associate/ Senior Research Associate – Lung Alveolar Epithelial Cell Biology (University of Southern California)

Scientist – Mesenchymal Cell Function in Chronic Lung Disease (Helmholtz Zentrum München)

PhD Position – Airway Inflammation (University of Heidelberg)

PhD Studentship – Toxicology (CRP – Gabriel Lippmann)


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