Volume 1.01 | Dec 20

Pulmonary Cell News 1.01 December 20, 2012
Pulmonary Cell News
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Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia
Researchers studied ion transport in newborn nasal and tracheal/bronchial epithelia in tissues, cultures, and in vivo. CFTR-/- epithelia showed markedly reduced Cl and HCO3 transport. [Cell] Abstract | Graphical Abstract

PUBLICATIONS (Ranked by impact factor of the journal)

Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial Cell Integrity
Results highlighted epithelial Pten as a crucial gatekeeper controlling acute lung injury and lung fibrosis by modulating alveolar epithelial cell integrity, and the Pten/PI3K/Akt pathway as a potential therapeutic target in these intractable diseases. [Am J Respir Crit Care Med] Abstract

Exome Sequencing Identifies Mutations in CCDC114 as a Cause of Primary Ciliary Dyskinesia
To identify mutations that cause primary ciliary dyskinesia, the authors performed exome sequencing on six unrelated probands with ciliary outer dynein arm defects. Mutations in CCDC114, an ortholog of the Chlamydomonas reinhardtii motility gene DCC2, were identified in a family with two affected siblings. [Am J Hum Genet] Abstract

Haemophilus influenzae Protein F Mediates Binding to Laminin and Human Pulmonary Epithelial Cells
Researchers showed that Protein F promotes binding of Haemophilus influenzae to laminin and primary bronchial epithelial cells. Analyses with recombinant proteins and synthetic peptides revealed that the N-terminal part of Protein F contains the host-interacting region. [J Infect Dis] Abstract

Imaging and Characterization of Stretch-Induced ATP Release from Alveolar A549 Cells
In the lungs, stretch is an important physical stimulus but its impact on ATP release, the underlying release mechanisms and transduction pathways are poorly understood. Scientists investigated the effect of unidirectional stretch on ATP release from human alveolar A549 cells by real-time luciferin-luciferase bioluminescence imaging coupled with simultaneous infrared imaging, to monitor the extent of cell stretch and to identify ATP-releasing cells. [J Physiol] Abstract

Ciliated Cells of Pseudostratified Airway Epithelium do Not Become Mucous Cells after OVA Challenge
Since pseudostratified airway epithelium contains distinct progenitor cells from simple columnar airway epithelium, the lineage relationships of progenitor cells to mucous cells may be different in these two epithelial types. Researchers therefore performed lineage tracing of the ciliated cells of the murine basal cell-containing airway epithelium in conjunction with the ovalbumin (OVA)-induced murine model of allergic lung disease. [Am J Respir Cell Mol Biol] Abstract


Interleukin 23 Regulates Proliferation of Lung Cancer Cells in a Concentration-Dependent Way in Association with the Interleukin-23 Receptor
Direct effects of interleukin 23 (IL-23) on tumor cells have been reported rarely, and contradictory effects have been observed. Researchers studied such effects of IL-23 in lung cancer cells in vitro and in vivo and explored the underlying mechanism. They found IL-23 receptor expression in tissues from lung adenocarcinoma and small cell carcinoma but not in lung squamous cell carcinoma tissue. [Carcinogenesis] Abstract

Acquired Differential Regulation of Caspase-8 in Cisplatin-Resistant Non-Small-Cell Lung Cancer
Failure to efficiently induce apoptosis contributes to cisplatin resistance in non-small-cell lung cancer (NSCLC). Researchers found that in H460 NSCLC cells, caspase-8 cleavage was induced by cisplatin and is dependent on death receptor 4, death receptor 5, Fas-associated protein with death domain, acid sphingomyelinase and ceramide synthesis. [Cell Death Dis] Full Article

PRR11 Is a Novel Gene Implicated in Cell Cycle Progression and Lung Cancer
Investigators isolated and identified a novel gene, proline-rich protein 11 (PRR11), implicated in both cell cycle progression and lung cancer. PRR11 was overexpressed at both mRNA and protein levels in lung cancer tissues as compared with normal lung tissues. [Int J Biochem Cell Biol] Abstract

Adeno-Associated Virus Vector Mediated Expression of an Oncogenic Retroviral Envelope Protein Induces Lung Adenocarcinomas in Immunocompetent Mice
JSRV is a simple betaretrovirus that causes contagious lung cancer in sheep known as ovine pulmonary adenocarcinoma and closely resembles human lung adenocarcinoma. The authors employed the use of a strong JSRV enhancer-promoter combination to express the JSRV envelope at high levels and demonstrated for the first time, lung tumor induction in immunocompetent mice. [PLoS One] Full Article

Effect of ARHI on Lung Cancer Cell Proliferation, Apoptosis and Invasion In Vitro
Researchers aimed to elucidate the effects of ARHI (aplysia ras homolog I) on several biological features of lung cancer cells, including growth, proliferation and invasion, to collect experimental evidence for the future biological treatment of human lung cancer. [Mol Biol Rep] Abstract

Training Course: Culture Primary Human Bronchial Epithelial Cells at the Air-Liquid Interface


Oncothyreon Announces that L-BLP25 (Stimuvax®) Did Not Meet Primary Endpoint of Improvement in Overall Survival in Pivotal Phase III Trial in Patients with Non-Small Cell Lung Cancer
Oncothyreon Inc. announced that the pivotal Phase II clinical trial of L-BLP25 (formerly referred to as Stimuvax®) known as START did not meet its primary endpoint of an improvement in overall survival in patients with unresectable, locally advanced stage IIIA or stage IIIB non-small cell lung cancer. [Oncothyreon, Inc.] Press Release

NHS in England Funds KALYDECO™ (ivacaftor), the First Medicine to Treat the Underlying Cause of Cystic Fibrosis, for People with a Specific Genetic Mutation
Vertex Pharmaceuticals Incorporated announced that a decision has been made by the National Health Service in England to fund KALYDECO™ (ivacaftor), the first medicine to treat the underlying cause of cystic fibrosis, for people ages 6 and older who have at least one copy of the G551D mutation in the cystic fibrosis transmembrane conductance regulator gene. [Vertex Pharmaceuticals Inc.] Press Release

Dr. Victor Tapson, Pulmonary Disease, Is Named One of America’s Top Doctors®
Dr. Victor Tapson , a Raleigh, NC physician who is Board Certified in Pulmonary Disease, has been selected by Castle Connolly Medical Ltd. for inclusion in its prestigious guide of the nation’s top 1% of medical specialists, America’s Top Doctors. [PR Newswire Association LLC] Press Release


American Lung Association Applauds Environmental Protection Agency Decision to Protect Public from Soot
The American Lung Association applauds the Obama Administration’s decision to set a much stronger national air quality standard on particulate matter (soot), one of the nation’s most lethal air pollutants. [American Lung Association, United States] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW 15th World Conference on Lung Cancer
Oct. 27-30, 2013
Sydney, Australia

Visit our events page to see a complete list of events in the pulmonary cell community.


Product Quality Scientist (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies, Inc.)

Scientist or Engineer – hPSC Bioengineer (STEMCELL Technologies, Inc)

W2 Professorship – Diffuse Parenchymal Lung Disease (Justus-Liebig-University Giessen)

Postdoctoral Position – Fibrosis in Chronic Lung Disease (Research Institute of the McGill University Health Center)

Postdoctoral Fellow – Pulmonary Research (University of Texas Health Science Center at Tyler)

Staff Scientist – Cardiovascular Pulmonary (National Institutes of Health – Dept of Health and Human Services)

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