Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection

[Cell] Investigators compared exopolysaccharide-producers versus non-producers and a virulent Escherichia coli lung infection model in male and female mice.

KN046, a Bispecific Antibody against PD-L1 and CTLA-4, Plus Chemotherapy as First-Line Treatment for Metastatic NSCLC: A Multicenter Phase II Trial

[Cell Reports Medicine] In this multicenter phase II trial, patients with nonsquamous (non-sq) NSCLC receive pemetrexed, whereas those with sq-NSCLC receive paclitaxel, plus KN046 and carboplatin. Following four cycles, maintenance therapy included KN046 with pemetrexed for non-sq-NSCLC and KN046 for sq-NSCLC.

Activation of Polyamine Catabolism Promotes Glutamine Metabolism and Creates a Targetable Vulnerability in Lung Cancer

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists reported that activation of polyamine catabolism promoted glutamine metabolism, leading to a targetable vulnerability in lung cancer.

Enigmatic Exosomal Connection in Lung Cancer Drug Resistance

[Molecular Therapy - Nucleic Acids] Investigators summarize the current knowledge on conventional and emerging drug resistance mechanisms and the involvement of exosomes as well as exosome-mediated factors mediating drug resistance in lung cancer.

Abnormal Expression of Krüppel-Like Transcription Factors and Their Potential Values in Lung Cancer

[Heliyon] The authors review the recent some progresses of the oncogenic Krüppel-like factors with their potential values for diagnosis, prognosis and molecular target in lung cancer.

£1.7 Million for the World’s First Vaccine to Prevent Lung Cancer

[Cancer Research UK] Researchers at the University of Oxford, the Francis Crick Institute and University College London have been granted £1.7 million of funding from Cancer Research UK and the CRIS Cancer Foundation to develop a lung cancer vaccine.

Deciphering Fibroblast-Induced Drug Resistance in Non-Small Cell Lung Carcinoma Through Patient-Derived Organoids in Agarose Microwells

[Lab On A Chip] Investigators introduced an agarose microwell platform designed for patient-derived organoid-based tumor and tumor microenvironment models, enabling rapid drug screening and resistance studies with small sample volumes.

Auranofin Repurposing for Lung and Pancreatic Cancer: Low CA12 Expression as a Marker of Sensitivity in Patient-Derived Organoids, with Potentiated Efficacy by AKT Inhibition

[Journal Of Experimental & Clinical Cancer Research] Our investigation employed a comprehensive drug screening of Auranofin in combination with eleven anticancer agents in cancerous PDAC and NSCLC patient-derived organoids, and non-cancerous pulmonary organoids.

Stimulatory Effect of Methylglyoxal on Capsaicin-Sensitive Lung Vagal Afferents in Rats: Role of TRPA1

[American Journal Of Physiology-Regulatory Integrative And Comparative Physiology] Scientists showed that intravenous injection of methylglyoxal in anesthetized, spontaneously breathing rats elicited pulmonary chemoreflexes characterized by apnea, bradycardia, and hypotension.

Bile Acid Metabolites Enhance Expression of Cathelicidin Antimicrobial Peptide in Airway Epithelium through Activation of the TGR5-ERK1/2 Pathway

[Scientific Reports] Researchers investigated the effects of bile acid metabolites produced from lithocholic acid by microbiota, on the regulation of innate immune responses connected to the expression of host defense peptide cathelicidin in lung epithelial cells.

Lung Repair and Regeneration: Advanced Models and Insights into Human Disease

[Cell Stem Cell] Scientists summarize recent research on the cellular complexity of the mammalian respiratory system with a focus on gas exchange and immunological defense functions of the lung.

UM Air Pollution Research Facility Receives $4.8 Million

[University of Manitoba] The new UM AirSAFE lab will be Canada’s first multi-disciplinary research centre for biomedical, engineering, natural science and occupational health experts to study how inhaled pollutants impact health and disease.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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